实验动物为7周龄Wistar系雄性大鼠,尾静脉给予甘薯块根皮提取物(50mg/kg),24h后测定血糖及血中胰岛素值,并进行糖耐量试验(葡萄糖2g/kg,po;0.5g/kg,iv)。 尾静脉内单剂量给予组与经口给药2周时具有同等强度的胰岛素分泌促进作用,经口及腹腔内单剂量给药未见该效果。认为其原因是活性成分为高分子化合物。探讨尾静 The experimental animals were 7-week-old male Wistar rats. The sweet potato root bark extract (50 mg/kg) was administered intravenously. Blood glucose and blood insulin were measured 24 h later, and glucose tolerance test (glucose 2 g/kg, po; 0.5) was performed. g/kg,iv). In the tail vein single-dose administration group, the same level of insulin secretion promotion effect was observed at the time of oral administration of 2 weeks, and this effect was not seen by oral and intraperitoneal single-dose administration. The reason for this is thought to be that the active ingredient is a macromolecular compound. Exploring the tail