缺氧诱导因子 1(HIF -1)是一种主要由缺氧诱导细胞产生的重要的转录因子。HIF- 1的表达水平与糖酵解、细胞周期阻滞、细胞生存与增殖、血管新生、血管舒缩、红细胞生成、肿瘤生长,转移以及肿瘤多药耐药等许多生命活动密切相关。HIF- 1通过调控凋亡相关基因的转录在促细胞凋亡和抗细胞凋亡中都发挥着重要的作用。 Hypoxia-inducible factor 1 (HIF-1) is an important transcription factor that is mainly produced by hypoxia-inducible cells. The expression level of HIF-1 is closely related to many life activities such as glycolysis, cell cycle arrest, cell survival and proliferation, angiogenesis, vasomotion, erythropoiesis, tumor growth, metastasis and multidrug resistance of tumor. HIF-1 plays an important role in pro-apoptotic and anti-apoptosis by regulating the transcription of apoptosis-related genes.