论文部分内容阅读
本文进行了分别由三个厂家生产的法莫替丁在１０例正常志愿者中的药代动力学研究。１０例正常志愿者交叉口服由温州，青岛及国外生产的２片法莫替丁片（每片２０ｍｇ），用ＨＰＬＣ法测定法莫替丁的血浆浓度和回收率。研究结果表明：药代动力学符合开放性二室模型。主要药代动力学参数如下：温州组：Ｔ_（ｐｅａｋ）＝２．０１±０．３４ｈ，Ｃ_（ｍａｘ）＝１６６．１０±４２．９６μｇ·ｈ~（－１）·Ｌ~（－１），Ｔ_（１／２）β＝２．３８±０．５２ｈ，ＣＬｒ＝１２．０６±２．１８ｌ／ｈ，ＡＵＣ＝９２０．２０±１３０．００μｇｈ~（－１）·Ｌ~（－１）；青岛组：Ｔ_（ｐｅａｋ）＝１．８７±０．３４ｈ，Ｃ_（ｍａｘ）＝１７７．０８±３３．３８μｇ·ｈ~（－１）·Ｌ~（－１），Ｔ_（１／２）β＝２．６４±０．６９ｈ，ＣＬｒ＝１２．０７±２．２５ｌ／ｈ，ＡＵＣ＝９３７．２３±１１７．００μｇ·ｈ~（－１）·Ｌ~（－１）；国外组：Ｔ_（ｐｅａｋ）＝１．９４±０．５８ｈ，Ｃ_（ｍａｘ）＝１６５．８０±３８．１３μｇ／１，Ｔ_（１／２）β＝２．５１±０．６１ｈ．Ｃｌｒ＝１２．０４±２，４２１／ｈ，ＡＵＣ＝８９４．３３±１３０．７３μｇ·ｈ~（－１）·Ｌ~（－１）。
In this paper, the pharmacokinetics of famotidine produced by three manufacturers in 10 normal volunteers were studied. Ten normal volunteers were given oral crossover tablets of famotidine (20 mg each) produced in Wenzhou, Qingdao and abroad. The plasma concentration and recovery of famotidine were determined by HPLC. The results show that: pharmacokinetics consistent with the open two-compartment model. The main pharmacokinetic parameters were as follows: Wenzhou group: T_ (peak) = 2.01 ± 0.34h, C_max = 166.10 ± 42.96μg · h -1 · L -1 , T ½ (1/2) β = 2.38 ± 0.52h, CLr = 12.06 ± 2.18l / h, AUC = 920.20 ± 130.00μgh -1 · L -1, ; Qingdao group: T_ (peak) = 1.87 ± 0.34h, C_max = 177.08 ± 33.38μg · h -1 L -1, T 1/2, β = 2.64 ± 0.69h, CLr = 12.07 ± 2.25l / h, AUC = 937.23 ± 117.00μg · h -1 · L -1; Peak = 1.94 ± 0.58h, C_max = 165.80 ± 38.13μg / 1, T_ (1/2) β = 2.51 ± 0.61h. Clr = 12.04 ± 2.21 / h, AUC = 894.33 ± 130.73μg · h -1 · L -1.