我院常以回收的输液瓶生产10%氯化钾注射液等,按常规生产,澄明度合格率不高,放置后有异物。笔者从两个方面查原因:1药物质量及生产环节如:控制原料质量、浓配加炭、更换微孔滤膜等,注意操作的各环节,结果仍不够理想。2从包装如瓶子,参照过去关于去离子水中硅酸检查方法,首先对250m输液瓶中硅酸进行了初步实验检查,发现澄明度不高是硅酸含量过高的结果。现将实验报告于后。一、仪器与试剂50ml钠氏比色管。硅酸(H_2SiO_3)AR,5%钼酸铵试液、1%维生素C容液(临用时配制)、草硫混酸试液[1份硫酸(16mol/L)与3份4%草酸溶液混匀]。二、方法与结果1.标准液的制备精密称取硅酸50mg,加氢氧化钠试液10ml加热使之溶解后,加稀硫酸5 ml,然后加硝酸(1→8)1 ml,将此液全部转入500ml容量瓶中,加蒸锱水至刻度摇匀(100ug/ml)。再精密吸取此液1 ml置100ml容量瓶中,用蒸馏水稀释至刻度即得(每ml含硅酸1 ug)。2.测定方法精密吸取上述标准液,1、 Our hospital often to the recovery of infusion bottles of 10% potassium chloride injection, according to conventional production, clarity pass rate is not high, there are foreign objects after placement. I check the reasons from two aspects: 1 drug quality and production processes such as: control of raw material quality, with carbonation, replacement of microporous membrane, pay attention to all aspects of the operation, the result is still not good enough. 2 from the packaging, such as bottles, with reference to the past on the deionized water silicic acid inspection method, first of 250m infusion bottle of silicic acid conducted a preliminary experimental examination and found that clarity is not high clarity is the result of excessive content of silicic acid. Now the experiment report later. First, the instrument and reagent 50ml sodium colorimetric tube. (H_2SiO_3) AR, 5% ammonium molybdate test solution, 1% vitamin C solution (ready to use), grass sulfur mixed acid test solution [1 part sulfuric acid (16mol / L) and 3 parts of 4% oxalic acid solution ]. Second, the method and results 1. Preparation of standard solution Precision weighed silicic acid 50mg, add sodium hydroxide test solution 10ml heated to dissolve, add dilute sulfuric acid 5 ml, then add nitric acid (1 → 8) 1 ml, this All the liquid into 500ml volumetric flask, add distilled water to shake (100ug / ml). Then draw 1 ml of this solution into a 100 ml volumetric flask and dilute to the mark with distilled water (1 ug / ml silicic acid). 2. Determination of precision drawing the above standard solution, 1,