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目的 :研究血清、尿液Ⅳ型胶原 (T4C)水平与 2型糖尿病肾病 (DN)的关系。方法 :2型糖尿病(DM)患者 182例 ,分为正常蛋白尿组 (DMN组 ) ,微量蛋白尿组 (DMMA组 ) ,大量蛋白尿组 (DMP组 ) ;对照组(C组 ) 31例 ,检测血清T4C ,尿液T4C、Cr。结果 :①血清T4C在DMN组与C组区别无显著性 ,在DMMA组高于C组和DMN组 (P <0 .0 1) ,DMP组高于C组、DMN组 (P <0 .0 1)和DMMA组 (P <0 .0 5 ) ;尿T4C/Cr在DMN组与C组差异无显著性 ,在DMMA组、DMP组明显高于C组 (P <0 .0 1) ,DMP组较DMN组明显升高 (P <0 .0 5 ) ,但与DMMA组差异无显著性。②相关分析显示 :DM患者尿Alb/Cr与尿T4C/Cr(r=0 .2 35 ,P <0 .0 1)、血清T4C(r=0 .376 ,P <0 .0 1)均呈显著的正相关。结论 :2型DM患者血、尿T4C与尿Alb排出有一致性升高的趋势。尿T4C是晚期DN指标 ;血清T4C既是DM早期肾病的指标 ,也是晚期DN指标。
Objective: To study the relationship between serum and urinary level of type Ⅳ collagen (T4C) and type 2 diabetic nephropathy (DN). Methods: A total of 182 patients with type 2 diabetes mellitus (DM) were divided into three groups: DMN group, DMEM group, DMP group, 31 cases in control group (C group) Detection of serum T4C, urine T4C, Cr. Results: Serum T4C was not significantly different between DMN group and C group, higher in DMMA group than in C group and DMN group (P <0.01), DMP group was higher than C group, DMN group (P <0. 0) 1) and DMMA group (P <0. 05). Urinary T4C / Cr showed no significant difference in DMN group and C group, but higher in DMMA group and DMP group than that in C group (P <0.01) Group than DMN group was significantly higher (P <0. 05), but no significant difference with the DMMA group. ② Correlation analysis showed that urine Alb / Cr and urine T4C / Cr (r = 0.235, P <0.01), serum T4C (r = 0.376, P <0.01) Significant positive correlation. Conclusions: There is a consistent increase in blood and urine T4C and urine Alb excretion in patients with type 2 DM. Urine T4C is a late DN index; serum T4C is both DM early nephropathy index, but also advanced DN indicators.