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目的:研究化合物ent-kaur-16-en-19-oic acid对小鼠S180瘤株的抑制作用。方法:称取定量的ent-kaur-16-en-19-oic acid,用食用植物油溶解后,加入等量吐温-80,充分搅拌后加入8倍量蒸馏水配制成所需浓度的溶液。将已接种S180瘤株的小鼠模型24h后随机分组,各组均连续给药8天,停药后1天将小鼠脱颈椎处死,剥取瘤称重。结果:ent-kaur-16-en-19-oic acid有明显抑制S180实体瘤的作用,高、中剂量组抑瘤率均在40%以上。结论:ent-kaur-16-en-19-oicacid有一定的抗肿瘤活性。
Objective: To study the inhibitory effect of ent-kaur-16-en-19-oic acid on mouse S180 tumor cells. Methods: Quantitative ent-kaur-16-en-19-oic acid was weighed, dissolved in edible vegetable oil, added with Tween-80 in equal amount, mixed with 8 times of distilled water to prepare the solution with the required concentration. The mice that had been inoculated with S180 tumor cells were randomly divided into groups of 24 hours and each group was continuously administered for 8 days. The mice were sacrificed one day after the withdrawal and the tumors were weighed. Results: The effect of ent-kaur-16-en-19-oic acid on S180 solid tumors was significantly inhibited. The tumor inhibition rates of high and medium dose groups were over 40%. Conclusion: ent-kaur-16-en-19-oicacid has certain anti-tumor activity.