论文部分内容阅读
給烏拉坦麻醉兔靜脉注射烏藜芦混合碱2—5微克/公斤,血压立即下降,10分钟的最低降压面积分別为27.0±7.7%和47.8±15.5%,降压时間維持30至60分钟。重复給药不見有急性耐受現象。两侧迷走神經切断对烏藜芦碱的降压作用沒有影响,切断两侧竇神經,小量(1—2微克/公斤)的烏藜芦碱引起血压升高,而大量(5—10微克/公斤)則主要引起血压下降。用猫进行同样实驗获得类似結果。根据以上資料,我們认为:在保留竇神經的麻醉动物,小剂量烏藜芦混合碱的降压作用主要通过兴奋頸动脉竇区所致血管运动中樞的反射性抑制,而大剂量很可能对血管运动中樞也有直接抑制作用。
The intravenous injection of 2-5 ug / kg of veratrum mixed alkali into anesthetized rabbits in Utran immediately reduced the blood pressure to 27.0 ± 7.7% and 47.8 ± 15.5% for 10 minutes respectively, and the blood pressure time was 30-60 minute. Repeated administration of no acute tolerance phenomenon. Vagus nerve excision on both sides has no effect on the antihypertensive effect of veratridine, cut off the sinus nerves on both sides, small amount (1-2 micrograms / kg) of veratridine caused by high blood pressure, while a large number of (5-10 micrograms / Kg) is the main cause of blood pressure drop. Similar experiments with cats yielded similar results. Based on the above information, we believe that: in anesthetized animals that retain the sinus nerves, the hypotensive effect of the low dose of veratridine mixed base is mainly through the reflex inhibition of the vasomotor center caused by the excited carotid sinus, while high doses are likely to cause vascular Sports center also has a direct inhibitory effect.