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本文是以~(125)I标记P—IPA作指示剂,采用液体闪烁计数法,观察研究其在小白鼠体内的吸收、分布与积累。它为养猪生产实践中应用P—IPA制剂,在代谢理论上提供了某些依据。 小鼠肌注~(125)I—P—IPA制剂后,吸收较缓,1.5小时仅吸收注射量的23％,被吸收的P—IPA随即向各脏器转移和甲状腺选择性地捕捉,代谢速度变快,生物半衰期(T1/2)较短。分布与积累不均衡,3—6小时放射性在心、肝等软组织中含最高;6—48小时甲状腺含量明显增加。一周后,除甲状腺含最略高外,其它组织甚微。
In this study, P-IPA was labeled with ~(125)I as the indicator. The liquid scintillation counting method was used to observe its absorption, distribution and accumulation in mice. It uses P-IPA preparations for pig production practices and provides some basis for metabolic theory. After intramuscular injection of ~(125)I-P-IPA preparation, the mice absorbed slowly, and only 23% of the injection volume was absorbed in 1.5 hours. The absorbed P-IPA was then transferred to various organs and selectively captured by the thyroid gland. The speed becomes faster and the biological half-life (T1/2) is shorter. The distribution and accumulation are not balanced. The radioactivity in the heart and liver is the highest in 3-6 hours, and the thyroid content is increased in 6-48 hours. A week later, with the exception of the highest thyroid gland, other tissues were minimal.