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目的观察卡维地洛对急性心肌梗死(AMI)患者血管内皮依赖性舒张功能及血清氧化指标——丙二醛(MDA)的影响。方法将52例AMI患者随机分成卡维地洛治疗组(28例)和常规治疗组(24例),比较观测治疗8周前后超声检测肱动脉流量介导性扩张的血管内皮依赖舒张功能及血清MDA的变化。结果治疗前两组比较,内皮依赖性血管舒张功能差异无统计学意义;卡维地洛治疗8周后内皮依赖性血管舒张功能明显改善;血清MDA水平明显降低,与治疗前比较,差异均有统计学意义(P<0.05或P<0.01)。结论卡维地洛在治疗8周后通过降低血清MDA水平的抗氧自由作用,可明显改善AMI患者血管内皮依赖舒张功能。
Objective To observe the effects of carvedilol on endothelium-dependent vasodilatation and serum oxidation of malondialdehyde (MDA) in patients with acute myocardial infarction (AMI). Methods Fifty-two patients with AMI were randomly divided into carvedilol treatment group (n = 28) and conventional treatment group (n = 24). The changes of endothelium-dependent vasodilatation of brachial artery with flow-mediated dilation were observed before and 8 weeks after treatment. Changes in MDA. Results There was no significant difference of endothelium-dependent vasodilation between the two groups before treatment. Endothelium-dependent vasodilatation was significantly improved after 8 weeks of carvedilol treatment, and serum MDA level was significantly lower than that before treatment Statistical significance (P <0.05 or P <0.01). Conclusion Carvedilol can significantly improve the endothelium-dependent vasodilatation in AMI patients by reducing the antioxidant capacity of serum MDA level after 8 weeks of treatment.