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泛素化修饰对蛋白质降解及多种细胞功能都具有重要的调控作用,如DNA损伤修复、细胞周期调控、细胞生长、免疫系统功能等。泛素修饰酶锌指蛋白A20被认为是调控机体免疫和炎症反应的重要门户,为NF-κB信号通路中的关键负性调控因子。树突状细胞(DC)是专职的抗原提呈细胞,可以通过多种受体识别炎性反应或病原微生物,是维持机体免疫稳态的关键调节者。近年来,有研究表明,A20在DC功能的调控中发挥着重要作用,可能参与了炎症性肠病的发生和发展。文章基于最新的研究进展,总结A20对DC的免疫调控及其在炎症性肠病发病机制中的作用。
Ubiquitination modification of protein degradation and a variety of cell functions have an important regulatory role, such as DNA damage repair, cell cycle regulation, cell growth, immune system function. Ubiquitin-modifying enzyme zinc finger protein A20 is considered as an important gateway regulating the immune and inflammatory responses of the body and is a key negative regulator in the NF-κB signaling pathway. Dendritic cells (DCs) are specialized antigen-presenting cells that recognize inflammatory responses or pathogenic microorganisms through a variety of receptors and are key regulators of immune homeostasis. In recent years, some studies have shown that A20 plays an important role in the regulation of DC function and may be involved in the occurrence and development of inflammatory bowel disease. Based on the latest research progress, the article summarizes A20 DC immune regulation and its role in the pathogenesis of inflammatory bowel disease.