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Tumor microenvironment is composed of the tumor cells,stromal cells,microvascular tissue fluid,constitute small amount of infiltrating cells and cytokines.In recent years,more and more evidence that tumor microenvironment play an important role in tumorigenesis.Tumor cells,immune cells and other mesenchymal cells interact and create an immunosuppressive microenvironment through a variety of immunosuppressive factors which vascular endothelial growth factor(VEGF),transformed growth factor-β_1(TGF-β_1)and interleukin-10(IL-10)),which suppress immunology functions and promote tumor cells to escape immune surveillance,ultimately leading to tumor growth and metastasis.Dendritic cells(DCs),the most potent antigen presenting cell as now known,play a key role in the anti-tumor immune process.The pre-
Tumor microenvironment is composed of the tumor cells, stromal cells, microvascular tissue fluid, constitute small amount of infiltrating cells and cytokines.In recent years, more and more evidence that tumor microenvironment play an important role in tumorigenesis. Tumor cells, immune cells and other mesenchymal cells interact and create an immunosuppressive microenvironment through a variety of immunosuppressive factors which vascular endothelial growth factor (VEGF), transformed growth factor-β_1 (TGF-β_1) and interleukin-10 (IL-10) ultimately leading to tumor growth and metastasis. Dendritic cells (DCs), the most potent antigen presenting cell as now known, play a key role in the anti-tumor immune process. The pre-