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复制动物心律失常模型的方法很多,其中以药物诱发的方法较为常用。氯仿—肾上腺素诱发家兔心律失常早已被广泛应用,但此法对氯仿麻醉的深度不易掌握,因而影响模型的稳定性和实验结果。笔者用Sprague—Dawley(SD)品系大鼠为实验对象,摸索用肾上腺素(AD)诱发心律失常模型的规律性。现将初步结果报告如下。材料与方法一、动物和药品 SD大鼠由南京药物研究所提供,体重150～250克,周龄6～8周,雌雄兼用。盐酸肾上腺素注射液(AD)1mg/ml,北京制药厂产,批号840418。二、模型的建立麻醉用乌拉坦(20％溶液,新鲜配制)按1.2g/kg腹腔注射。手术将麻醉大鼠仰卧保定,切开腹股沟处皮肤,
There are many ways to reproduce animal arrhythmia models, of which drug-induced methods are more common. Chloroform - adrenergic induced arrhythmia in rabbits has been widely used, but this method is not easy to grasp the depth of chloroform anesthesia, thus affecting the stability of the model and experimental results. The author used Sprague-Dawley (SD) strain rats as experimental subjects to explore the regularity of adrenaline-induced arrhythmia model. The preliminary results are reported below. Materials and Methods First, animals and drugs SD rats provided by the Nanjing Institute of Materia Medica, weighing 150 to 250 grams, 6 to 8 weeks of age, both male and female. Adrenaline hydrochloride injection (AD) 1mg / ml, Beijing Pharmaceutical Factory production, batch number 840418. Second, the model of anesthesia with urethane (20% solution, freshly prepared) by 1.2g / kg intraperitoneal injection. Surgical anesthesia rats supine Baoding, cut the groin at the skin,