膀胱癌是常见的恶性肿瘤之一,复发率高。传统的诊断方法多有创伤性,检删方法敏感性和特异性不高。随着分子生物学发展,近年来发现了6种新的膀胱癌特异性核基质蛋白,其中尿液BLCA-4蛋白对膀胱癌早期诊断具有较好的临床应用前景,现就BLCA-4蛋白研究现状进行综述。 Bladder cancer is one of the common malignant tumors with a high recurrence rate. Traditional diagnostic methods are more traumatic, deleterious deletion method sensitivity and specificity is not high. With the development of molecular biology, in recent years, six kinds of new bladder cancer-specific nuclear matrix proteins have been found. The urine BLCA-4 protein has a good clinical application prospect in the early diagnosis of bladder cancer. Status quo review.