Neuronal circuitry reconstruction after stem cell therapy in damaged brain

来源 :中国神经再生研究(英文版) | 被引量 : 0次 | 上传用户:zhuzhihua
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Transplantation of neuronal precursors derived from human pluripotent stem cells is a promising therapy for the treatment of neurological disorders associated with neuronal loss,such us neurodegenerative diseases,brain trauma and stroke.The functional integration of grafted neurons differentiated from stem cells into the host injured neuronal circuitry has been a major challenge in cell therapy strategies for brain repair (Palma-Tortosa et al.,2021).Even though other cell types or mechanisms may provide modest clinical improvements,neuronal replacement and reconstruction of the damaged area are crucial for an optimal and long-term recovery.
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