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目的评价季铵盐类消毒剂毒性,为实际应用提供安全性依据。方法采用动物试验方法,对一种固体季铵盐消毒剂进行了一般毒性实验研究。结果该季铵盐消毒剂对小鼠急性经口LD50为762.2 mg/kg,大鼠急性经口LD50为986.0 mg/kg。亚急性毒性试验各剂量组动物体重、血细胞计数及分类、血生化指标与对照组比较均无显著性差异,动物主要脏器未见明显病理变化。结论该季铵盐消毒剂的急性作用主要与其消化道直接毒性有关,对大小鼠属低毒;未发现该季铵盐消毒剂有明显亚急性毒性作用。
Objective To evaluate the toxicity of quaternary ammonium salt disinfectant and provide a safety basis for its practical application. Methods The animal experiment method was used to study the general toxicity of a solid quaternary ammonium salt disinfectant. Results The acute oral LD50 of the quaternary ammonium disinfectant was 762.2 mg / kg in mice and the acute oral LD50 in rats was 986.0 mg / kg. Subacute toxicity test of each dose group of animal body weight, blood cell count and classification, blood biochemical indicators compared with the control group no significant difference in the main organs of animals showed no significant pathological changes. Conclusion The acute effects of the quaternary ammonium disinfectant are mainly related to its direct toxicity to the digestive tract, and are of low toxicity to rats and rats. No obvious subacute toxic effects have been found on the quaternary ammonium disinfectants.