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目的研究冰冻病理学在宫颈上皮内瘤变(CIN)的诊断和治疗中的作用和其准确性。方法回顾性分析160例经阴道镜诊断为宫颈上皮内瘤变Ⅱ级(CINⅡ)和Ⅲ级(CINⅢ)的患者,在行宫颈冷刀锥切术中运用冰冻病理检查(FSE)诊断治疗和进行切除子宫术后,再运用石蜡病理检查(PS)对宫颈锥切术的标本和子宫切除术后的所有标本进行检查,对比冰冻病理检查和石蜡病理检查的结果 ,以及两种方法对标本组织切缘病灶情况的阳性和阴性判断。结果通过对比两种方法的结果可以发现,术中运用冰冻病理检查(FSE)和术后运用石蜡病理检查(PS),两者对病情诊断治疗的结果基本相符,相符率为90.0%,但是,经过宫颈冷刀锥切术和切除子宫术后,均取得了良好的疗效。两种方法判断组织切缘病灶的阴阳性结果完全相符。结论通过分析对比可以发现,冰冻病理检查应用于宫颈上皮内瘤变的诊治中能取得一定的诊治效果。
Objective To study the role and accuracy of frozen pathology in the diagnosis and treatment of cervical intraepithelial neoplasia (CIN). Methods A retrospective analysis of 160 cases of cervical intraepithelial neoplasia grade Ⅱ (CIN Ⅱ) and Ⅲ grade (CIN Ⅲ) diagnosed by colposcopy was performed in the diagnosis of cervical cold knife conization with frozen pathological examination (FSE) After removal of the uterus, and paraffin pathological examination (PS) specimens of cervical conization and hysterectomy after all the specimens were examined, compared with the results of frozen pathological examination and paraffin pathological examination, and two methods of tissue culture Edge lesions of the positive and negative judgments. Results By comparing the results of two methods, we found that the coincidence rate was 90.0% according to the results of pathological diagnosis and treatment using both frozen pathological examination (FSE) and postoperative paraffin pathological examination (PS) After cervical cold knife conization and excision of the uterus, have achieved good results. Two methods to judge the positive and negative results of tissue-edge lesions exactly match. Conclusion Through the analysis and comparison, we can find that frozen pathological examination can be used in the diagnosis and treatment of cervical intraepithelial neoplasia to achieve a certain diagnosis and treatment effect.