目的 探讨降钙素原(PCT)水平对小儿重症感染患者接受抗生素治疗的指导意义.方法 选取2014年1月-2016年2月在广元市中心医院接受治疗的66例患儿为研究对象,且入院时均未使用抗生素,记录其入院时体温、PCT、C反应蛋白(CRP)、外周血白细胞(WBC)水平以及预后情况.采用电化学发光法进行检测并分析和比较抗生素治疗前后患儿的PCT、CRP、WBC水平.根据感染的程度及PCT、WBC检查结果对患儿进行分组,其中重症细菌感染患儿19例为A组、局部细菌感染患儿17例为B组,非细菌感染患儿30例为C组,比较3组患儿的PCT、CRP、WBC的差异.结果 A组PCT,CRP,WBC的值均明显升高;B组CRP显著升高,而PCT,WBC轻度升高;C组PCT,CRP,WBC升高均不明显.A组与B组PCT,CRP,WBC水平比较,差异有统计学意义(P＜0.05);A组与C组PCT,CRP,WBC水平比较,差异有统计学意义(P＜0.05);B组与C组PCT,CRP水平比较,差异有统计学意义(P＜0.05),而WBC的水平比较,差异无统计学意义(P＞0.05).结论 PCT水平对早期诊断临床细菌感染及判断细菌感染轻重有一定价值.动态检测PCT测定结果有利于评估抗生素的治疗效果,对合理应用抗生素治疗有较高的指导作用.“,”Objective To explore the guiding significance of procalcitonin (PCT) level for antibiotic therapy in children with severe infection.Methods Sixty-six children treated in Guangyuan Municipal Central Hospital from January 2014 and February 2016 were selected,and they were not treated by antibiotics at admission.The temperature,the levels of PCT,C-reactive protein (CRP),white blood cell (WBC) count in peripheral blood and prognosis at admission were recorded.Electrochemiluminescence was used to detect,analyze,and compare the levels of PCT,CRP,and WBC count before and after treatmeut.The children were divided into group A (19 children with severe bacterial infection),group B (17 children with local bacterial infection),and group C (30 children without bacterial infection) according to the severity of infection and the levels of PCT and WBC count.The levels of PCT,CRP,and WBC count in the three groups were compared.Results The mean levels of PCT,CRP,and WBC count in group A inc reased significantly;the mean level of CRP in group B increased significantly,while the mean levels of PCT and WBC count in group B increased slightly;the increases of mean levels of PCT,CRP,and WBC count in group C were not significant.There were statistically significant differences in the mean levels of PCT,CRP,and WBC count between group A and group B,group C,respectively (P＜0.05).There were statistically significant differences in the mean levels of PCT and CRP between group B and group C (P＜0.05),but there was no statistically significant difference in the mean level of WBC count between group B and group C (P＞0.05).Conclusion PCT mean level has a certain value in early diagnosis of clinical bacterial infection and determination of bacterial infection.Dynamic detection of PCT levels contributes to evaluation of therapeutic effect of antibiotics,which has high guiding significance for rational application of antibiotics.