本文报告在血浓度监测下对327例癫痫病人进行卡马西平、苯妥英钠耐受性研究的结果。发现:4％的癫痫病人对卡马西平有先天耐受性,6.1％的病人高敏,6％有代谢性耐受。对苯妥英钠的先天和代谢性耐受为2.7％,高敏者占8.1％。另外,本资料也显示病人对苯妥英钠和卡马西平的某些不良反应,存在着有益的功能性耐受。结合文献,本文对耐受性的分类、特征和可能的机理进行了复习。 This article reports the results of a study of 327 patients with epilepsy undergoing carbamazepine and phenytoin sodium tolerance monitoring at blood concentrations. Found: 4% of epilepsy patients have congenital tolerance to carbamazepine, 6.1% of patients with high sensitivity, 6% of metabolic tolerance. The congenital and metabolic tolerance to phenytoin was 2.7%, with hyper-sensitivity accounting for 8.1%. In addition, this data also shows patients with some adverse reactions to phenytoin sodium and carbamazepine, there is a useful functional tolerance. Combined with the literature, this article reviews the classification, characteristics and possible mechanisms of tolerance.