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ivATP-MgCl_2能够显著缩小麻醉犬冠状动脉闭塞6h后的心肌梗塞面积,抑制肌酸磷酸激酶(CPK)和谷氨酸-草酰乙酸转氨酶(GOT)的释放,其作用优于单纯ATP或单纯MgCl_2,同时,亦能抑制麻醉家兔结扎冠状动脉6h后的CPK和GOT的释放。提示ATP-MgCl_2,对缺血性心肌有明显的保护作用。
ivATP-MgCl 2 can significantly reduce myocardial infarct size 6 h after coronary artery occlusion in anesthetized dogs and inhibit the release of creatine phosphokinase (CPK) and glutamate-oxaloacetate transaminase (GOT), which is superior to ATP alone or MgCl 2 alone. At the same time, it can also inhibit the release of CPK and GOT after anesthetized rabbits ligated coronary artery for 6 hours. It is suggested that ATP-MgCl 2 has a significant protective effect on ischemic myocardium.