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1,2,4-三氯苯(简称1,2,4-TCB)是工业合成的中间产物,为一无色液体,难溶于水,有苦辣的芳烃化合物的味道,嗅阈约为3ppm。大鼠、兔、猴慢性吸入中毒实验(1,2,4-TCB纯度为99.07%):吸入浓度分别为0、25、50、100ppm,7小时/日/周,共26周。每组雄性大鼠30只、雄兔16只、雄猴9只。中毒组的监测平均浓度分别为25.3,49.2和92.8ppm。[观察指标] 肺功能检查,包括肺静态的应变性,CO扩散能力、通气分布、肺体积和呼吸阻力等,每组选3只猴经训练后用于实验中测定动作行为(operant behavior)。生化指标包括血清谷草转氨酶(SGOT)、
1,2,4-trichlorobenzene (referred to as 1,2,4-TCB) is an intermediate of industrial synthesis, a colorless liquid, insoluble in water, bitter aromatic compound smell, the smell of about 3ppm. Rats, rabbits, monkeys chronic inhalation toxicity test (1,2,4-TCB purity of 99.07%): inhalation concentrations were 0,25,50,100 ppm, 7 hours / day / week for a total of 26 weeks. Thirty male rats in each group, 16 male and 9 male. The average concentrations of the poisoning groups were 25.3, 49.2 and 92.8 ppm, respectively. [Observations] Lung function tests, including static lung strain, diffusivity of CO, ventilation distribution, lung volume and respiratory resistance, were used to determine the operant behavior in the experiment. Biochemical indicators include serum aspartate aminotransferase (SGOT),