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目的探讨胃溃疡采用埃索美拉唑和奥美拉唑治疗的临床效果。方法 106例胃溃疡患者,按照随机数字对照法分为对照组和研究组,各53例。对照组先进行幽门螺杆菌(Hp)根除三联方案治疗,2周后采用奥美拉唑治疗6周;研究组首先进行Hp根除三联方案治疗,2周后采用埃索美拉唑治疗6周,对比两组临床疗效。结果研究组总有效率86.8%高于对照组的73.6%(P<0.05)。研究组的Hp根除率为90.6%,对照组的Hp根除率为66.0%,比较差异具有统计学意义(P<0.05)。对照组出现不良反应4例(7.5%),研究组无显著不良反应,两组不良反应发生率比较差异有统计学意义(P<0.05)。结论埃索美拉唑治疗胃溃疡效果显著,能够有效控制病情且无毒副作用,适于在临床推广使用。
Objective To investigate the clinical efficacy of esomeprazole and omeprazole in the treatment of gastric ulcer. Methods One hundred and sixty patients with gastric ulcer were divided into control group and study group according to random number control method, with 53 cases in each. The control group was treated with Helicobacter pylori (Hp) first and then with omeprazole for two weeks. The study group was treated with Hp eradication triple therapy first and esomeprazole two weeks later for 6 weeks. Compare two groups clinical curative effect. Results The total effective rate was 86.8% in the study group and 73.6% in the control group (P <0.05). The study group Hp eradication rate was 90.6%, control group Hp eradication rate was 66.0%, the difference was statistically significant (P <0.05). There were 4 adverse reactions in the control group (7.5%). There was no significant adverse reactions in the study group. There was significant difference in the incidence of adverse reactions between the two groups (P <0.05). Conclusion Esomeprazole is effective in treating gastric ulcer. It can effectively control the disease and has no toxic and side effects and is suitable for clinical use.