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上海寄生虫病研究所研制的抗疟药7351(苯骈萘啶类新药)经过二年(1971年～1972年)来的口服试用,证明其疗效不低于氯喹,而副反应却比氯喹低,动物实验与氯喹无交叉抗药性。为了抢救凶险型疟疾的需要,1973年进行了7351针剂对实验动物的疗效与毒性试验,并与氯喹针剂作平行比较。各项试验证明,7351针剂的疗效显著,毒性显著比氯喹为低,具有高效、速效、低毒的特点,可过渡到临床试用。
Shanghai Institute of Parasitic Diseases developed anti-malarial drug 7351 (Benzene naphthyridine drugs) after two years (1971 ~ 1972) to the oral trial to prove that its efficacy is not less than chloroquine side effects than chloroquine low , Animal experiments and chloroquine no cross-resistance. In order to save the need for dangerous malaria, the efficacy and toxicity test of 7351 injection on experimental animals was carried out in 1973 and compared with that of chloroquine injection. Various experiments have shown that 7351 injection significantly curative effect, significantly lower toxicity than chloroquine, with high efficiency, quick effect, low toxicity, can transition to clinical trials.