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目的探讨A型肉毒毒素(BoTX-A)对人体交感神经功能的影响。方法在BoTX-A注射前及注射后1周分别于注射部位[偏侧面肌痉挛(HFS)-Meige综合征(Meige)/额部,痉挛性截瘫/大腿内侧]及非注射部位(手掌)处记录双侧交感神经皮肤反应(SSR)。结果注射后1周4例HFS-Meige(4/21,19%)及2例痉挛性截瘫(2/2,100%)患者注射部位未引出肯定SSR波形;其余可引出SSR的17例HFS-Meige患者中注射侧额部潜伏期由(946.1±83.8)ms延长至(1029.1±83.7)ms(P=0.048)。注射前、后所有患者手掌处均可引出SSR,但注射后潜伏期由(1306.5±162.1)ms延长至(1430.5±142.8)ms(P=0.007),波幅由(2656.8±1088.2)μV减低至(1840.7±809.2)μV(P=0.007)。结论BoTX-A可影响注射部位及远隔部位交感皮肤反应,且注射部位变化更明显。
Objective To investigate the effect of botulinum toxin type A (BotTX-A) on the function of human sympathetic nerve. Methods Before injection of BoTX-A and at 1 week after injection, rats were sacrificed at the site of injection [MeSH / frontal, spastic paraplegia / thigh] and non-injection site Bilateral sympathetic tone skin reaction (SSR) was recorded. Results Positive SSR waveform was not induced at 4 weeks after injection in 4 cases of HFS-Meige (4 / 21,19%) and 2 cases of spastic paraplegia (2 / 2,100%). The rest of 17 HFS-Meige patients The latency of the frontal forebrain was prolonged from (946.1 ± 83.8) ms to (1029.1 ± 83.7) ms (P = 0.048). SSR was induced in the palms of all patients before and after injection, but the latency was prolonged from (1306.5 ± 162.1) ms to (1430.5 ± 142.8) ms after injection (P = 0.007), and the amplitude decreased from (2656.8 ± 1088.2) μV to (1840.7 ± 809.2) μV (P = 0.007). Conclusion BoTX-A can affect the injection site and distant parts of the sympathetic skin reaction, and the injection site changes more pronounced.