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~(99m)T_c-5-PMT(~(99m)T_c-N-吡哆-5甲基色安酸)于1982年首由日本学者M.Kato Azulne提出作为优良的肝胆显像剂。1984和1985年,日本长谷川义尚首先报告将~(99m)T_c-PMT用于肝细胞癌及其转移灶的阳像,取得了令人鼓舞的结果。我院亦于1984性显年6月开始用~(99m)T_c-PMT进行肝肿瘤显像,到1988年10月底止共作了308例次,其中131例经手术病理证实。131例中,原发性肝癌104例,肝细胞腺瘤3例,肝海绵状血管瘤12例,继发性肝癌5例,肝囊肿2例,胆管细胞癌、肝脂肪变性、新生肝、肝手术疤痕及肝硬化各1例。研究结果证明~(99m)T_c-PMT延迟显像诊断原发性肝癌的灵敏度为61.6％,将异性为95.8％。特别适用于原发性肝癌的定位诊断,和原发性肝癌转移灶及AFP阴性病人的定位和定性诊断。本法
The ~(99m)T_c-5-PMT(~(99m)T_c-N-pyrrolidine-5-methylsuccinic acid) was first proposed by Japanese scholar M.Kato Azulne as an excellent hepatobiliary imaging agent in 1982. In 1984 and 1985, Japan’s Hasegawa Masahiro first reported the use of ~(99m)T_c-PMT for positive images of hepatocellular carcinoma and its metastatic lesions, with encouraging results. In our hospital in 1984, we started to use ~(99m)T_c-PMT for liver tumor imaging in June of the same year. By the end of October 1988, a total of 308 cases were performed, of which 131 were confirmed by pathology. Among the 131 cases, 104 were primary hepatocellular carcinoma, 3 hepatocellular adenomas, 12 hepatic cavernous hemangiomas, 5 hepatic hepatocellular carcinomas, 2 hepatic cysts, cholangiocellular carcinoma, hepatic steatosis, neonatal hepatic diseases, and liver disease. Surgical scars and cirrhosis were found in 1 patient each. The results showed that the sensitivity of ~(99m)T_c-PMT delayed imaging in the diagnosis of primary liver cancer was 61.6%, and the heterosexuality was 95.8%. It is particularly suitable for the localization diagnosis of primary liver cancer, and the localization and qualitative diagnosis of primary liver cancer metastases and AFP-negative patients. This law