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目前国内外常用血铅、尿铅作为诊断铅中毒或铅吸收的主要依据之一,但上述指标基本上是反映体内铅负荷,并非表明铅其毒性,且操作繁琐,易受污染,故有一定的缺点。为此,有人试图用测定机体受铅毒作用后的异常代谢产物来代替。锌原卟啉(ZnPP)是慢性铅吸收全血中出现的主要异常代谢产物,其操作方法简易、迅速,可作为职业铅接触的快速筛选指标。我们观察了铅接触者全血ZnPP量的变化,并初步探讨其在铅中毒防治工作中的意义。
At present, blood lead and urine lead are commonly used as the main basis for diagnosing lead poisoning or lead absorption. However, the above indexes basically reflect the lead load in the body and do not indicate the toxicity of lead and are cumbersome to operate and easy to be contaminated. Therefore, Shortcomings. To this end, some people try to use the body to determine the role of lead poisoning after abnormal metabolites to replace. Zinc protoporphyrin (ZnPP) is the main abnormal metabolite in chronic lead absorption whole blood. Its operation method is simple and rapid, which can be used as a rapid screening index for occupational lead exposure. We observed changes in the amount of ZnPP in whole blood of lead-exposed patients and explored its significance in the prevention and control of lead poisoning.