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目的:对掌叶大黄化学成分进行研究。方法:运用硅胶、聚酰胺、凝胶等柱层析等方法进行化合物的分离纯化,通过波谱分析和理化鉴别进行化合物的结构鉴定。结果:从掌叶大黄中分离鉴定了9个化合物,分别为2,5-二甲基-6,8-二羟基色原酮(1),1-甲基-2,8-二羟基-3-羧基-9,10-蒽醌(2),ω-羟基大黄素(3),4′-羟基苯基-2-丁酮(4),4′-羟基苯基-2-丁酮-4′-O-β-D-(2″-O-没食子酰基-6″-O-(4′′′-羟基)-桂皮酰基)-葡萄糖苷(5),反式-3,5,4′-三羟基二苯乙烯-4′-O-β-D-(6″-O-没食子酰基)-葡萄糖苷(6),4′-羟基苯基-2-丁酮-4′-O-β-D-(6″-O-桂皮酰基)-葡萄糖苷(7),4′-羟基苯基-2-丁酮-4′-O-β-D-(6″-O-(4′′′-羟基)-桂皮酰基)-葡萄糖苷(8),反式-3,5,4′-三羟基二苯乙烯-4′-O-β-D-葡萄糖苷(9)。结论:化合物1、2为新化合物。
Objective: To study the chemical constituents of Rheum palmatum. Methods: The compounds were isolated and purified by column chromatography, such as silica gel, polyamide and gel chromatography. Their structures were elucidated by spectral analysis and physical and chemical identification. Results: Nine compounds were isolated and identified from Rheum palmatum, which are 2,5-dimethyl-6,8-dihydroxychromone (1), 1-methyl-2,8-dihydroxy-3 (2), ω-hydroxy emodin (3), 4’-hydroxyphenyl-2-butanone (4), 4’-hydroxyphenyl- -O-β-D- (2 “-O-galloyl-6” -O- (4’’hydroxy) -cinnamoyl) -glucoside (5), trans-3,5,4 ’ (6 “-O-galloyl) -glucoside (6), 4’-hydroxyphenyl-2-butanone-4’-O-β -D- (6 ”-O-cinnamoyl) -glucoside (7), 4’-O-β-D- -hydroxy-cinnamoyl) -glucoside (8), trans-3,5,4’-trihydroxystilbene-4’-O-β-D-glucoside (9) .CONCLUSION: Compound 1 , 2 is a new compound.