论文部分内容阅读
目的:分析腹腔镜下根治术联合紫杉醇与卡铂(TC)化疗方案治疗晚期卵巢癌的效果。方法:抽取2018年7月至2019年6月郑州大学第三附属医院收治的晚期卵巢癌患者77例，均行腹腔镜根治术，依据术后化疗方案分为两组，对照组38例术后给予吉西他滨与顺铂化疗方案，观察组39例术后给予TC化疗方案。回顾性比较两组肿瘤因子水平、T淋巴细胞亚群、化疗期间不良反应及复发情况。结果:观察组化疗2个周期基质金属蛋白酶-9、人附睾蛋白4、促红细胞生成素均低于对照组，差异有统计学意义(n t＝4.497、16.189、3.383，n P＝0.001、0.001、0.002)。化疗2个周期，观察组CD3n ＋、CD4n ＋水平均高于对照组(n t＝2.865、3.227，n P＝0.005、0.002)，CD8n ＋水平低于对照组(n t＝3.415，n P＝0.001)。观察组化疗期间不良反应发生率(21.04%，8/38)低于对照组(5.12%，2/39), n P<0.05。观察组随访1年内复发率为2.56%(1/39)，对照组为7.89%(3/38)，两组比较差异未见统计学意义(χn 2＝1.110，n P＝0.292)。n 结论:腹腔镜下根治术联合TC化疗方案更利于降低晚期卵巢癌患者肿瘤因子水平，改善T淋巴细胞亚群水平，且不良反应少，复发率低。“,”Objective:To analyze the effect of laparoscopic radical resection combined with taxol and carboplatin (TC) chemotherapy in the treatment of advanced ovarian cancer.Methods:A total of 77 patients with advanced ovarian cancer admitted to the Third Affiliated Hospital of Zhengzhou University from July 2018 to June 2019 underwent radical laparoscopic surgery. They were divided into two groups according to the postoperative chemotherapy regimen, 38 patients in the control group were given gemcitabine and cisplatin chemotherapy after surgery and 39 patients in the observation group were given TC chemotherapy after surgery. the levels of tumor factors, T lymphocyte subsets, adverse reactions during chemotherapy and recurrence were compared retrospectively between the two groups.Results:The matrix metalloproteinase-9, human epididymal protein 4, and erythropoietin in the observation group were lower than those in the control group during the 2 cycles of chemotherapy, and the differences were significant (n t=4.497, 16.189, 3.383, n P=0.001, 0.001, 0.002). After 2 cycles of chemotherapy, the CD3n + and CD4n + levels in the observation group were higher than those in the control group (n t=2.865, 3.227, n P=0.005, 0.002), and the CD8+ level in the observation group was lower than that in the control group (n t=3.415, n P=0.001). The incidence of adverse reactions during chemotherapy in the observation group (21.04%, 8/38) was lower than that in the control group (5.12%, 2/39), n P<0.05. The recurrence rate in the observation group was 2.56% (1/39) within 1 year of follow-up, and that in the control group was 7.89% (3/38), the difference was not significant between the two groups (χn 2=1.110, n P=0.292).n Conclusions:Laparoscopic radical resection combined with TC chemotherapy is more beneficial to reduce the level of tumor factors in patients with advanced ovarian cancer, improve the level of T lymphocyte subsets, and have fewer adverse reactions and low recurrence rates.