巴比妥(Barbitalum)为目前常用的镇静催眠剂之一,过去一般药典是以杂质检查及测定物理常数保证其质量,苏联药典规定以酸量法测定其含量,我国新药典草案采用在碳酸钠存在下以银量法进行测定。此二法均不够稳定,终点难于掌握,为寻找较好的含量测定方法,进行了巴比妥及其片剂含量测定方法的研究。 Barbitalum (Barbitalum) is one of the commonly used sedatives and hypnotics. In the past, the general pharmacopoeia adopted the method of impurity examination and determination of the physical constants to ensure its quality. The Soviet Union Pharmacopoeia stipulated that the content of the drug should be determined by the acidometric method. In the presence of silver measurement method. The two methods are not stable enough, the endpoint is difficult to grasp, in order to find a better determination of content, the method of determination of barbiturates and tablets were studied.