痘病毒是所有病毒中最大、最复杂的病毒。致死性的正痘病毒仍然威胁着人类的健康。虽然在20世纪70年代末,世界卫生组织宣布天花病毒已经在全球范围内被消灭,但是,还是存在天花出现的可能性。因此,各国科学家仍在积极寻找能够有效对抗天花病毒及其他能够导致疾病和死亡的痘病毒的药物。西多福韦是全球研究最多、最深入的一个药物,其余处于研究阶段的药物还包括常用的抗病毒药、酶抑制剂及其他核苷类药物等。 Poxvirus is the largest and most complex of all viruses. Lethal orthopoxviruses still threaten human health. Although in the late 1970s, the World Health Organization announced that the smallpox virus had been eliminated on a global scale, the possibility of smallpox still existed. Therefore, scientists from various countries are still actively looking for drugs that can effectively fight VARV and other poxviruses that can cause diseases and deaths. Cidofovir is the most researched and most in-depth drug in the world. The remaining drugs in the research phase include commonly used antiviral drugs, enzyme inhibitors and other nucleoside drugs.