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目的:探讨儿童原发性肾小球疾病中医辨证与肾脏病理积分的关系。方法:选择91例临床诊断为原发性肾小球疾病的患儿进行传统的中医辨证,对其肾活检光镜病理进行统一的半定量积分,并比较中医辨证与病理积分的相关性。结果:脾肾阳虚证的肾小球、肾小管间质及肾脏总病理损害积分>气阴两虚>肝肾阴虚>肺肾气虚。结论:儿童原发性肾小球疾病中医辨证与肾脏病理积分显著相关。随着中医辨证为肺肾气虚、肝肾阴虚、气阴两虚和脾肾阳虚的不同证型,肾脏病理损害程度进行性加重。
Objective: To investigate the relationship between syndrome differentiation of traditional Chinese medicine (TCM) and nephrotic pathology in children with primary glomerular disease. Methods: Ninety-one children diagnosed as primary glomerular diseases were selected to carry out traditional TCM syndrome differentiation. The semi-quantitative integration of kidney biopsy was performed, and the correlation between TCM syndrome differentiation and pathological score was compared. Results: The spleen and kidney yang deficiency glomeruli, tubulointerstitial and kidney pathological damage integral> Qi and Yin Deficiency> liver and kidney yin deficiency> lung qi and kidney deficiency. Conclusion: There is a significant correlation between syndrome differentiation of TCM and pathological score of kidney in children with primary glomerular disease. With the differentiation of traditional Chinese medicine for the lung and kidney Qi, liver and kidney, Qi and Yin deficiency and spleen and kidney yang different syndromes, the severity of renal pathology worsened.