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目前市场上的氟喹诺酮类药物相对于其它类抗生素有满意的安全性。氟喹诺酮类药物在老年人中广泛使用,易产生心脏心律失常。因为潜在的心脏疾病、代谢紊乱和抗心律失常药物和其它延长QT间隔的药物的使用,新的氟喹诺酮类药物的心脏毒性问题已被提出。某些不理想的氟喹诺酮类药物由于安全问题已从市场上撤出。 尖端扭转型定性心动过速(Torsadede points)发生频率如何?一份世界卫生组织1983～1999年的761例的报告中,有34例(4.8％)是致命的。在瑞典,一项32家医院1个月的调查中,420万人中有68例心室心动过速症,其中14例为尖端扭
Fluoroquinolones currently on the market have satisfactory safety compared to other antibiotics. Fluoroquinolones are widely used in the elderly, prone to cardiac arrhythmias. Cardiac toxicity issues with the new fluoroquinolones have been proposed because of potential heart disease, metabolic disorders, and antiarrhythmic drugs and other drugs that prolong the QT interval. Some of the less preferred fluoroquinolones have been withdrawn from the market due to safety concerns. How often does Torsadede points occur? A World Health Organization report of 761 cases from 1983 to 1999 showed that 34 (4.8%) were fatal. In a one-month survey of 32 hospitals in Sweden, 68 of 4.2 million people had ventricular tachycardia, of which 14 were torsionally twisted