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目的:通过检测宫腔粘连患者子宫内膜整合素ανβ3的表达,探讨宫腔粘连患者子宫内膜容受性的改变。方法:选择经宫腔镜诊断宫腔粘连的患者35例(研究组),因男性不育于我院行人工授精治疗的患者30例作为对照组,于“种植窗期”检测两组患者血清雌激素(E2)及孕酮(P)水平,同时免疫组化SP法检测两组患者子宫内膜组织中整合素ανβ3的表达水平。结果:两组患者“种植窗期”血清E2及P水平差异无统计学意义(P>0.05);研究组子宫内膜整合素ανβ3表达水平明显低于对照组,差异有统计学意义(P<0.01),重度宫腔粘连患者整合素ανβ3表达水平明显低于轻、中度宫腔粘连患者,差异有统计学意义(P<0.01)。结论:宫腔粘连患者子宫内膜整合素ανβ3的异常表达,可能导致子宫内膜容受性下降,并引起不孕、流产。
OBJECTIVE: To investigate the changes of endometrial receptivity in patients with intrauterine adhesions by detecting the expression of integrin ανβ3 in uterine cavity of patients with intrauterine adhesions. Methods: Thirty-five patients (research group) who underwent hysteroscopy to diagnose intrauterine adhesions were enrolled in this study. Thirty patients with male infertility treated by artificial insemination in our hospital were selected as control group. Serum estradiol (E2) and progesterone (P) levels were detected in patients with endometriosis. The expression of integrin ανβ3 in endometrium was detected by immunohistochemical SP method. Results: There was no significant difference in E2 and P levels between the two groups (P> 0.05). The expression level of integrin ανβ3 in the study group was significantly lower than that in the control group (P <0.05) P <0.01). The expression of integrin αvβ3 in patients with severe intrauterine adhesions was significantly lower than that in patients with mild or moderate uterine adhesions (P <0.01). Conclusion: The abnormal expression of integrin ανβ3 in patients with intrauterine adhesions may lead to decreased endometrial receptivity and cause infertility and abortion.