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本文以香叶醇为原料首次成功地合成了天然大环二萜化合物Cembrene-C(1),关键步骤是砜化合物(6)与氯代物(8)的相转移催化偶联反应及低价钛诱导的二羰基化合物(12)的选择性环合反应。
In this paper, the natural macrocyclic diterpene compound Cembrene-C (1) has been successfully synthesized for the first time using geraniol as the starting material. The key steps are the phase transfer catalysis coupling reaction of the sulfone compound (6) with the chlorinated material (8) Induction of the selective cyclisation of the dicarbonyl compound (12).