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聚乳酸(PLA)是一种新型的高分子聚合物,不溶于水、乙醇,可溶于二氯甲烷(DCM)、丙酮等。PLA无免疫原性,它以玉米为主要原料,合成及改性技术已经趋于成熟。PLA和乳酸-羟基乙酸共聚物(PLGA)都具有良好的生物相容性,在体内最终代谢为二氧化碳和水,是可用于人体的生物降解材料。PLA有良好的力学性能,也有亲水性不足等缺点,为改善药物的靶向性及释药速度,常需要对其进行修饰。与其他靶向释药系统相比,微球具有制备较简单、稳定性好成本低等特点,为近年来研究的热点。不过有些
Polylactic acid (PLA) is a new type of polymer, insoluble in water, ethanol, soluble in dichloromethane (DCM), acetone and so on. PLA non-immunogenicity, it is corn as the main raw material, synthesis and modification technology has become mature. PLA and lactic acid - glycolic acid copolymer (PLGA) have good biocompatibility, the final metabolism in the body of carbon dioxide and water, is a biodegradable material for the human body. PLA has good mechanical properties, but also has disadvantages such as insufficient hydrophilicity. In order to improve drug targeting and drug release rate, PLA often needs to be modified. Compared with other targeted drug delivery systems, microspheres have the characteristics of simple preparation, good stability and low cost, which are the hot topics in recent years. But some