c-fos和c-jun等即早反应基因(Immediate-early genes,lEGs)的主要特征是对生理和病理刺激能作快速、瞬时性表达,表达的Fos和Jun再与功能或结构蛋白基因(缓早反应基因,Late-early genes,LEGs)中的AP-1等位点结合,诱导LEGs的表达,从而产生生理或病理效应,神经损伤后的再生修复是包括一系列分子、细胞瀑布式事件的病理生理过程,有报道用免疫反应法可测出脊髓背角神经元中Fos的长时间表达,但腹角运动神经元为阴性反应. The main features of c-fos and c-jun immediate-early genes (lEGs) are the rapid and transient expression of physiological and pathological stimuli, the expression of Fos and Jun and the functional or structural protein gene ( Late-early genes, LEGs) in the AP-1 and other sites to induce the expression of LEGs, resulting in physiological or pathological effects, regeneration and repair after nerve injury is a series of molecular, cellular waterfall events Of the pathophysiological process, it has been reported by immunoreactivity method can be measured spinal dorsal horn neurons in long-term expression of Fos, but ventral horn motor neurons is negative.