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【目的】观察白术升降汤联合琥珀酸普芦卡必利治疗慢性功能性便秘的效果。【方法】将60例慢性功能性便秘患者随机分为治疗组和对照组,每组各30例,治疗组给予白术升降汤联合琥珀酸普芦卡必利治疗,对照组给予单纯口服琥珀酸普芦卡必利治疗,观察2组患者的中医证候疗效、便秘症状改善疗效、随访疗效和疗程结束后3个月的复发情况。【结果】(1)中医证候疗效:治疗组和对照组的治愈率分别为90.0%、60.0%,治疗组的中医证候疗效优于对照组(P<0.05)。(2)便秘症状改善疗效:治疗组和对照组的显效率分别为93.3%、50.0%,总有效率分别为100.0%、73.3%,2组比较,治疗组的便秘症状改善疗效优于对照组(P<0.05或P<0.01)。(3)随访疗效:治疗期内每周完全自发排便≥3次患者的比例,治疗组为86.7%,对照组为53.3%,治疗组的随访疗效优于对照组(P<0.05)。(4)疗程结束后3个月随访,治疗组1例复发,对照组6例复发,治疗组的复发例数明显少于对照组,差异有统计学意义(P<0.05)。【结论】中药白术升降汤结合琥珀酸普芦卡必利治疗慢性功能性便秘,疗效满意,既可以更好地改善患者的便秘情况,又可以降低复发率。
【Objective】 To observe the effect of Baizhu Shengqiu Decoction combined with succucalide succinate on chronic functional constipation. 【Methods】 Sixty patients with chronic functional constipation were randomly divided into treatment group and control group, with 30 cases in each group. The treatment group was treated with Baizhu Shengjiang Decoction combined with propafenone succinate, while the control group was treated with simple oral succinic acid Carbaryl treatment, observed two groups of patients with Chinese medicine syndrome efficacy, constipation symptoms to improve the efficacy, follow-up efficacy and recurrence after 3 months of treatment. 【Results】 (1) Therapeutic effect of TCM syndromes: The cure rates of the treatment group and the control group were 90.0% and 60.0% respectively. The curative effect of TCM syndrome in the treatment group was better than that in the control group (P <0.05). (2) Symptoms of constipation were improved: the effective rates of the treatment group and the control group were 93.3% and 50.0%, respectively, and the total effective rates were 100.0% and 73.3% respectively. In the two groups, the improvement of constipation was better in the treatment group than in the control group (P <0.05 or P <0.01). (3) The follow-up curative effect: The proportion of patients with complete spontaneous defecation ≥3 times a week during the treatment period was 86.7% in the treatment group and 53.3% in the control group. The follow-up effect in the treatment group was better than that in the control group (P <0.05). (4) Three months after the end of treatment, one case recurred in the treatment group and six cases in the control group relapsed. The number of recurrent cases in the treatment group was significantly less than that in the control group (P <0.05). 【Conclusion】 Atractylodes macrocephalae decoction combined with succucalide succinate in the treatment of chronic functional constipation has satisfactory curative effect, which can not only improve the patients’ constipation but also reduce the recurrence rate.