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2型糖尿病患者易罹患结直肠癌,若接受胰岛素治疗,则不仅结直肠癌发病率更高,且肿瘤进展更加迅速。高胰岛素血症假说认为,异常增高的胰岛素及游离胰岛素样生长因子-1水平可促进结肠细胞增殖,最终导致结直肠癌的发生。由于结直肠癌可通过筛选试验得以早期发现,故建议2型糖尿病患者均应选择合适的筛选形式,特别是接受胰岛素治疗的患者应建议进行结肠镜检查,并且筛选间隔时间不得超过5年。
Patients with type 2 diabetes are predisposed to colorectal cancer, receiving insulin therapy not only for a higher incidence of colorectal cancer but also for more rapid tumor progression. Hyperinsulinemia hypothesis that abnormally elevated insulin and free insulin-like growth factor-1 levels can promote colon cell proliferation, eventually leading to the occurrence of colorectal cancer. Since colorectal cancer can be detected early by screening test, it is recommended that patients with type 2 diabetes should choose the appropriate screening form, especially in patients receiving insulin therapy should be recommended for colonoscopy, and the screening interval of not more than 5 years.