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为制备仿细胞外基质支架材料,采用静电纺丝技术制备了玉米醇溶蛋白/鼠尾Ⅰ型胶原纳米纤维膜,研究了胶原含量对其纤维直径、亲疏水性、力学性能和生物相容性的影响.结果表明:胶原的最佳添加质量分数为26.7%.胶原的加入能够减小纤维直径,改善其亲水性,且提高其断裂伸长率,有利于更好地模拟细胞外基体组织结构;纤维膜毒性等级为1级,不存在潜在的细胞毒性;接种L929细胞0.5 h后细胞黏附率达60%以上,并且可以促进细胞增殖生长.实验说明该纳米纤维膜具有良好的生物相容性,可作为仿细胞外基质应用于组织工程领域.
In order to prepare the extracellular matrix scaffold material, zein Ⅰ / collagen Ⅰ nanofibrous membrane was prepared by electrospinning technique. The effects of collagen content on the fiber diameter, hydrophilicity, hydrophobicity, mechanical properties and biocompatibility .The results showed that the best mass fraction of collagen was 26.7% .The addition of collagen could reduce the diameter of fiber, improve the hydrophilicity and increase the elongation at break, which was beneficial to better simulate the extracellular matrix structure , And the cytotoxicity of fibroblasts was of grade 1 without potential cytotoxicity.The cell adhesion rate of L929 cells reached more than 60% after 0.5 h of inoculation and promoted the proliferation and proliferation of cells.Experiments showed that the nanofibrous membranes had good biocompatibility , Can be used as an extracellular matrix in tissue engineering.