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目的:探讨冠心病患者组织蛋白酶L(cathepsin L,CatL)水平的变化及其与炎症因子高敏C反应蛋白(hs-CRP)之间的关系。方法:测定137例冠心病患者(冠心病组)和48例非冠心病患者(对照组)的血清CatL水平和hs-CRP水平。结果:冠心病组、对照组的hs-CRP分别为(10.28±1.73)、(1.72±0.39)mg/L,2组比较,差异有统计学意义(P<0.01);冠心病组、对照组的CatL水平分别为(5.63±0.12)、(3.93±0.22)μg/L,2组比较,差异亦有统计学意义(P<0.01)。CatL与hs-CRP的相关性分析显示相关系数为0.339,P<0.01。结论:CatL可能与粥样斑块的破裂相关,CatL与hs-CRP呈显著正相关。
Objective: To investigate the changes of cathepsin L (CatL) and its relationship with inflammation factor high sensitive C-reactive protein (hs-CRP) in patients with coronary heart disease. Methods: Serum CatL levels and hs-CRP levels were measured in 137 patients with coronary heart disease (CHD) and 48 patients with non-CHD (control group). Results: The hs-CRP levels in CHD group and control group were (10.28 ± 1.73) and (1.72 ± 0.39) mg / L respectively, there was significant difference between the two groups (P <0.01) CatL levels were (5.63 ± 0.12) and (3.93 ± 0.22) μg / L, respectively. There was also a significant difference between the two groups (P <0.01). Correlation analysis between CatL and hs-CRP showed that the correlation coefficient was 0.339, P <0.01. Conclusion: CatL may be related to the rupture of atherosclerotic plaque, and there is a significant positive correlation between CatL and hs-CRP.