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观察自体瘤苗回植对恶性黑色素瘤患者免疫功能的影响。方法 :用 S- P一步法及免疫浊度法分别检测 30例恶性黑色素瘤患者自体瘤苗回植前后 NK细胞活性、 CD3、 CD4、 CD8、 CD4/CD8及 Ig A、 Ig G、 Ig M的水平 ,并比较其变化。结果 :治疗后 NK细胞活性、 CD3、 CD4、 CD4/CD8及 Ig G水平均显著升高 (P <0 .0 5 ) ,而 CD8、 Ig A、 Ig M无显著变化 (P >0 .0 5 )。结论 :自体瘤苗回植后能改善恶性黑色素瘤患者的免疫功能 ,尤以细胞免疫功能改善显著。
To observe the effect of autologous tumor vaccine on immune function in patients with malignant melanoma. Methods: The NK cell activity, CD3, CD4, CD8, CD4 / CD8 and Ig A, Ig G and Ig M of NK cells in 30 patients with malignant melanoma were detected by one-step S- Level, and compare its changes. Results: After treatment, NK cell activity, CD3, CD4, CD4 / CD8 and Ig G levels were significantly increased (P <0.05), but no significant changes in CD8, Ig A and Ig M ). Conclusion: The autologous tumor vaccine can improve the immune function of malignant melanoma patients, especially the improvement of cellular immune function.