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目的探讨中草药对肺炎链球菌的体外抑菌作用。方法用临床分离细菌为受试菌,采用琼脂稀释法,观察黄连、黄岑、黄柏和连翘等4种中草药水煎剂的最低抑菌浓度。结果4种中草药水煎剂均有不同程度的抑菌作用,其中黄连抑菌效果最好,黄连水煎剂对肺炎链球菌M IC范围达7.8~15.63 g/L,M IC50为8 g/L,M IC90为8 g/L。黄岑、黄柏也有较好的抑菌效果,连翘抑菌效果较弱。结论黄连等中药在体外对肺炎链球菌均有良好抑菌作用。
Objective To investigate the antibacterial effect of Chinese herbal medicine against Streptococcus pneumoniae in vitro. Methods The clinical isolates were used as test bacteria. The agar dilution method was used to observe the minimum inhibitory concentrations of four kinds of Chinese herbal decoctions, including Coptis chinensis, Radix Astragali, Phellodendron chinense, and Forsythia suspensa. Results The antibacterial activities of four kinds of Chinese herbal decoctions had different degrees. Among them, the antibacterial effect of Huanglian decoction was best. The range of Coptidis Rhizoma decoction against Streptococcus pneumoniae reached 7.8~15.63 g/L, and the IC50 of Mg was 8 g/L. The M IC90 is 8 g/L. Astragalus membranaceus and Phellodendron amurense have good antibacterial effects, and the antibacterial effect of Forsythia suspensa is weak. Conclusion Chinese medicine such as Rhizoma Coptidis has good antibacterial activity against Streptococcus pneumoniae in vitro.