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目的 制备盐酸吸入性急性肺损伤动物模型 ,测定其肺泡液体清除率。方法 32只大鼠随机分为 4组 ,对照组滴入pH为 7 4的 5 %等渗白蛋白溶液 ,酸吸入组分别滴注pH为 7 0、4 5、2 5的 5 %等渗白蛋白溶液 ,机械通气 1h后 ,测定其动脉血气、肺泡上皮屏障的通透性、肺泡液体清除率。结果 当滴注液pH值为 7 0时 ,其肺泡上皮对蛋白的通透性和对液体的清除率与对照组接近 ,动脉血氧分压无下降 (P >0 0 5 ) ;pH值为 4 5、2 5时 ,其肺泡上皮对蛋白的通透性和对液体清除率较对照组及pH 7 0组低 ,动脉血氧分压明显下降 (P <0 0 5 )。结论 肺泡上皮对酸损伤有一定的抵抗能力 ,高浓度盐酸溶液可损伤肺泡上皮和肺泡上皮屏障 ,使肺泡内液体不能及时清除 ,形成肺水肿
Objective To prepare an animal model of inhaled acute lung injury induced by hydrochloric acid and determine its alveolar fluid clearance rate. Methods Thirty-two rats were randomly divided into four groups. The control group was infused with 5% isotonic albumin solution of pH 7.4, and the acid inhalation group was instilled with 5% isotonic whiteness of 70,45,25 Protein solution, mechanical ventilation 1h after the determination of arterial blood gas, alveolar epithelial barrier permeability, alveolar fluid clearance. Results When the pH of the instilled solution was 70, the permeability of the alveolar epithelium to the protein and the clearance rate to the liquid were similar to those in the control group, and the partial pressure of arterial oxygen was not decreased (P> 0.05). The pH was At 45,25 hours, the alveolar epithelial permeability of the protein and the rate of liquid clearance were lower than those in the control group and pH group. The partial pressure of arterial oxygen decreased significantly (P <0.05). Conclusion The alveolar epithelium has a certain resistance to acid damage. High concentration hydrochloric acid solution can damage the alveolar epithelium and alveolar epithelial barrier so that the alveolar fluid can not be removed in time, resulting in pulmonary edema