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目的观察三维适形放疗(3DCRT)联合紫杉醇、顺铂同步化疗治疗局部晚期食管癌的近期疗效。方法局部晚期食管癌患者56例随机均分为两组,A组采用3DCRT联合化疗,B组行单纯3DCRT治疗。比较两组的近期疗效、生存率以及不良反应。结果所有患者均获随访1年以上。A组总有效率高于B组(89.3%vs.64.3%)(P<0.05)。A组1年生存率高于B组(85.7%vs.67.8%)(P<0.05)。A组的骨髓抑制和胃肠反应发生率明显高于B组(67.9%vs.17.9%和85.7%vs.25.0%)(P<0.05),但患者均能耐受。结论 3DCRT联合紫杉醇、顺铂同步化疗治疗局部晚期食管癌的近期疗效优于单纯放射治疗。
Objective To observe the short-term effect of three-dimensional conformal radiotherapy (3DCRT) combined with paclitaxel and cisplatin in the treatment of locally advanced esophageal cancer. Methods Fifty-six patients with locally advanced esophageal cancer were randomly divided into two groups. Group A received 3DCRT combined with chemotherapy and group B received simple 3DCRT. The two groups were compared the short-term efficacy, survival and adverse reactions. Results All patients were followed up for more than 1 year. The total effective rate in group A was higher than that in group B (89.3% vs.64.3%) (P <0.05). The 1-year survival rate of group A was higher than that of group B (85.7% vs.67.8%) (P <0.05). The incidence of bone marrow suppression and gastrointestinal reaction in group A was significantly higher than that in group B (67.9% vs.17.9% vs 85.7% vs.25.0%, P <0.05). Conclusion 3DCRT combined with paclitaxel and cisplatin concurrent chemotherapy for the treatment of locally advanced esophageal cancer is better than the simple radiotherapy.