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目的:评价血清网膜素-1(omentin-1)的水平与2型糖尿病患者合并冠心病的相关性。方法:182例2型糖尿病患者分为两组:未合并冠心病组(n=113)及合并冠心病组(n=69)。用酶联免疫吸附法(ELISA)测定患者血清omentin-1水平。结果:合并冠心病组患者血清omentin-1水平较未合并冠心病组患者显著降低[11.15(7.23～15.72)vs 18.95(10.27～22.46)ng.ml-1,P<0.01]。多元Logistic回归分析结果显示低血清omentin-1水平是2型糖尿病患者合并冠心病的独立危险因子(OR=0.605,95%可信区间0.299～0.883,P<0.01)。结论:血清omentin-1水平降低与2型糖尿病患者合并冠心病存在独立相关性,血清omentin-1可能成为预测2型糖尿病患者合并冠心病风险的重要的生物学标记物。
OBJECTIVE: To evaluate the relationship between serum level of omentin-1 and type 2 diabetes mellitus complicated with coronary heart disease. Methods: A total of 182 patients with type 2 diabetes were divided into two groups: uncorrected coronary heart disease group (n = 113) and coronary heart disease group (n = 69). Serum levels of omentin-1 were measured by enzyme-linked immunosorbent assay (ELISA). Results: The level of serum omentin-1 in patients with coronary heart disease was significantly lower than that in patients without coronary heart disease [11.15 (7.23 ~ 15.72) vs 18.95 (10.27 ~ 22.46) ng.ml-1, P <0.01]. Multivariate logistic regression analysis showed that low serum level of omentin-1 was an independent risk factor for type 2 diabetes complicated with coronary heart disease (OR = 0.605, 95% confidence interval 0.299-0.883, P <0.01). Conclusion: The serum level of omentin-1 is correlated with coronary heart disease in patients with type 2 diabetes mellitus independently. Serum omentin-1 may be an important biomarker to predict the risk of coronary heart disease in type 2 diabetic patients.