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目的:控制药费增长,促进抗高血压药的合理使用,为消费者选择高血压药物治疗的方案提供参考。方法:通过文献检索,收集并汇总26种常用抗高血压药有效性、安全性的信息;并以各种常用抗高血压药的每月平均药费范围上限为成本,降压有效率为效果,进行成本-效果分析,并在坐标轴中作散点图,寻找效果/成本比良好的品种。结果:抗高血压药总有效率为69.31%,药物不良反应总发生率为14.50%;氢氯噻嗪、卡托普利、阿替洛尔、美托洛尔、吲哒帕胺缓释片、硝苯地平缓释片、依那普利与氢氯噻嗪合用等都属于高效用药的范畴。结论:药物经济学中的效果/成本比可以在成本-效果坐标系中用直线的斜率来体现,鼓励使用基本药物和普通替代药的高效消费的用药行为。
OBJECTIVE: To control the increase of medical expenses, to promote the rational use of antihypertensive drugs and to provide a reference for consumers to choose the scheme of hypertension drug treatment. Methods: Through literature search, we collected and summarized the information of 26 commonly used antihypertensive drugs, and used the upper limit of monthly average drug cost of various commonly used antihypertensives as the cost and effective antihypertensive effect , Conduct cost-effectiveness analyzes, and scatter plots in the coordinate axes to find good / cost-effective breeds. Results: The total effective rate of antihypertensives was 69.31% and the total incidence of adverse drug reactions was 14.50%. Hydrochlorothiazide, captopril, atenolol, metoprolol, indapamide sustained-release tablets, Sustained release tablets, enalapril combined with hydrochlorothiazide, etc. belong to the category of efficient use of drugs. CONCLUSIONS: The effect / cost ratio in pharmacoeconomics can be expressed as a slope of a straight line in a cost-effectiveness coordinate system, encouraging efficient consumption of medications using both primary and generic alternatives.