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组蛋白脱乙酰基酶(histone deacetylases,HDACs)具有转录抑制功能,近年来发现其参与心血管系统的分化发育,调控多种刺激诱发的心肌肥大及其相关基因表达。本文就有关IIa型HDACs在心血管系统中作用的研究进展作一综述。
Histone deacetylases (HDACs) have transcriptional repression functions. In recent years, HDACs have been found to be involved in the development of cardiovascular system and to regulate cardiac hypertrophy and related gene expression induced by various stimuli. This review summarizes the advances in the role of Type IIa HDACs in the cardiovascular system.