抗心律失常药偶可引起新的心律失常或恶化已存在的心律失常。作者就抗心律失常药物治疗房颤或房扑时所致心律失常的发生率及其危害性进行描述。 1扭转性室速奎尼丁:1964年,Seizer等首先详细描述丁奎尼丁引起扭转。早年,英国非随机研究奎尼丁用于房颤复律后预防,对奎尼丁的安全性提出了些问题,在34例接受奎尼丁治疗者中2例死亡,1例发生了新的持续室速,而未接受预防的85例中未出现死亡,基于心脏事件,试验提前结束,奎尼丁用于预防失败。美国则相反,仍用奎尼丁预防房颤,并认为药物的安全性浓度在升高。于1970～1984年,在6个随机对比奎尼丁预防试验的一个二度分析中,Coplen等发现奎尼丁治疗的患者病死 Antiarrhythmic drugs can cause new arrhythmias or worsen an existing arrhythmia. The authors describe the incidence of arrhythmic events and the deleterious effects of antiarrhythmic drugs on atrial fibrillation or atrial flutter. 1 Torsional ventricular tachycardia Quinidine: In 1964, Seizer et al. First described in detail the reversal caused by dingquinidine. In the early years, non-randomized study of quinidine in the United Kingdom for the prevention of post-cardioversion afforded some questions about the safety of quinidine. Two of 34 patients died of quinidine and one had new Continued ventricular tachycardia, but did not receive prevention of 85 cases did not appear to die, based on cardiac events, the trial ended early, quinidine for the prevention of failure. On the contrary, the United States still use quinidine to prevent atrial fibrillation, and that the concentration of drug safety is on the rise. In a second analysis of six randomized quinidine prevention trials from 1970 to 1984, Coplen et al found that patients treated with quinidine died of disease