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目的:研究龙胆科(Gentianaceae)獐牙菜属狭叶獐牙菜(Swertia angustifolia Buch.)的化学成分。方法:采用硅胶柱层析和Sephadex LH-20柱层析分离纯化化合物,依据理化性质和现代波谱技术进行结构鉴定。结果:从乙酸乙酯部分分离鉴定了7个单体化合物,分别为香草酸(vanillic acid,1)、1,3,8-三羟基-5-甲氧基口山酮(1,3,8-trihydroxy-5-methoxy xanthone,2)、5,7,4′-三羟基二氢黄酮(5,7,4′-trihydroxy flavanone,3)、1-羟基-3,5,6-三甲氧基口山酮(1-Hydroxy-3,5,6-trimethoxy xanthone,4)、3,4-二羟基苯甲酸甲酯(methy-3,4-dihydroxy-benzoate,5)、邻苯二甲酸二异丁酯(diisobutyl phthalate,6)、1,8-二羟基-3,5-二甲氧基口山酮(methyl-bellidifolin,7)。结论:化合物1~7均为首次从狭叶獐牙菜中分离得到。
Objective: To study the chemical constituents of Swertia angustifolia Buch. From Gentianaceae. Methods: The compounds were isolated and purified by silica gel column and Sephadex LH-20 column chromatography. Their structures were elucidated on the basis of physico-chemical properties and modern spectroscopic techniques. Results: Seven monomer compounds were isolated and identified from the ethyl acetate fraction, which were vanillic acid (1), 1,3,8-trihydroxy-5-methoxy colorantone -trihydroxy-5-methoxy xanthone, 2), 5,7,4’-trihydroxyflavanone (3), 1 -hydroxy-3,5,6-trimethoxy 1-Hydroxy-3,5,6-trimethoxyxanthone (4), methy-3,4-dihydroxy-benzoate (5) Diisobutyl phthalate (6) and 1,8-dihydroxy-3,5-dimethoxycholine (7). Conclusion: Compounds 1 ~ 7 were isolated from Swertia tenuiflora for the first time.