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目的探讨早期测定血清可溶性髓系细胞触发受体-1(sTREM-1)在诊断急性加重期慢性阻塞性肺疾病(AECOPD)患者合并肺部细菌感染中的价值。方法应用定量酶联免疫吸附法(ELISA)检测60例AECOPD患者的血清sTREM-1水平,并将sTREM-1水平与临床肺部感染评分(CPIS)进行相关性分析。结果 AECOPD在细菌感染组血清sTREM-1水平明显高于无细菌感染组(P均<0.05)。根据ROC曲线,sTREM-1曲线下面积为0.930,95%可信区间为0.840～1.020,诊断效能好。且与CPIS评分呈正相关(r=0.246,P<0.05)。结论早期测定血清sTREM-1水平对AECOPD患者合并肺部细菌感染的诊断有一定价值,可以为病情或感染严重程度的评估提供有意义的参考指标。
Objective To investigate the value of early detection of soluble myeloid cell trigger receptor-1 (sTREM-1) in the diagnosis of pulmonary bacterial infection in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Serum levels of sTREM-1 in 60 patients with AECOPD were detected by quantitative enzyme-linked immunosorbent assay (ELISA), and the correlation between sTREM-1 level and clinical lung infection score (CPIS) was analyzed. Results The serum level of sTREM-1 in AECOPD group was significantly higher than that in non-bacterial group (all P <0.05). According to the ROC curve, the area under the curve of sTREM-1 was 0.930, the 95% confidence interval was 0.840 to 1.020, and the diagnostic efficiency was good. And positively correlated with CPIS score (r = 0.246, P <0.05). Conclusion The early determination of serum sTREM-1 level in the diagnosis of AECOPD complicated with pulmonary bacterial infection has some value, which can provide a meaningful reference index for the evaluation of disease or severity of infection.