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药品环吡酮胺阴道栓的主要成分环吡酮胺为吡酮类衍生物,是广谱类抗真菌药。其作用机制可能是通过结合细胞内的铁离子,引起真菌细胞铁离子缺乏进而影响到细胞内的生命代谢活性,最终发挥抗真菌作用[1]。《中华人民共和国药典(2010年版)》规定,在形成一种药品微生物限度检查的方法时应进行验证[2]。本文通过加入6种已知对照用菌株的方法进行实验,根据验证实验结果形成环吡酮胺阴道栓微生物限度的检查方法,现
Ciclopirox olamine vaginal suppository main component Ciclopirox olamine is a pyrazolone derivative, is a broad-spectrum antifungal agent. Its mechanism may be through the combination of intracellular iron ions, causing fungal iron ion deficiency and thus affect the metabolic activity of life within the cell, and ultimately play an anti-fungal effect [1]. “Pharmacopoeia of the People’s Republic of China (2010 Edition)” provides that in the formation of a method of microbial limit testing should be verified [2]. This article by adding six known control strains of the method of experiment, according to the results of the verification test ciclopirox olamine vaginal suppository microbial limit test method is